纳米载体
生物相容性
药物输送
药理学
壳聚糖
生物利用度
医学
糖尿病
纳米技术
材料科学
化学
内分泌学
生物化学
冶金
作者
Afshin Taheriazam,Maliheh Entezari,Zeinab Mohammadi Firouz,Shima Hajimazdarany,Mohammad Hossein Heydargoy,Amir Hossein Amin Moghadassi,Ali Moghadaci,Amin sadrani,Motahhar Motahhary,Abdorrahman Harif Nashtifani,Amirhossein Zabolian,Teimour Tabari,Mehrdad Hashemi,Rasoul Raesi,Mengyuan Jiang,Xuebin Zhang,Shokooh Salimimoghadam,Yavuz Nuri Ertaş,Dongdong Sun
标识
DOI:10.1016/j.envres.2023.115912
摘要
Nature-derived polymers, or biopolymers, are among the most employed materials for the development of nanocarriers. Chitosan (CS) is derived from the acetylation of chitin, and this biopolymer displays features such as biocompatibility, biodegradability, low toxicity, and ease of modification. CS-based nano-scale delivery systems have been demonstrated to be promising carriers for drug and gene delivery, and they can provide site-specific delivery of cargo. Owing to the high biocompatibility of CS-based nanocarriers, they can be used in the future in clinical trials. On the other hand, diabetes mellitus (DM) is a chronic disease that can develop due to a lack of insulin secretion or insulin sensitivity. Recently, CS-based nanocarriers have been extensively applied for DM therapy. Oral delivery of insulin is the most common use of CS nanoparticles in DM therapy, and they improve the pharmacological bioavailability of insulin. Moreover, CS-based nanostructures with mucoadhesive features can improve oral bioavailability of insulin. CS-based hydrogels have been developed for the sustained release of drugs and the treatment of DM complications such as wound healing. Furthermore, CS-based nanoparticles can mediate delivery of phytochemicals and other therapeutic agents in DM therapy, and they are promising compounds for the treatment of DM complications, including nephropathy, neuropathy, and cardiovascular diseases, among others. The surface modification of nanostructures with CS can improve their properties in terms of drug delivery and release, biocompatibility, and others, causing high attention to these nanocarriers in DM therapy.
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