成核
DNA缩合
DNA
冷凝
纳米技术
离子键合
材料科学
纳米尺度
DNA纳米技术
高分子
纳米颗粒
无定形固体
化学
离子
结晶学
有机化学
物理
基因
热力学
生物化学
转染
作者
Nuo Chen,Li Wang,Xiaojun Song,Yanjuan Li,Zhaoxiang Deng
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-10-31
卷期号:22 (21): 8550-8558
被引量:7
标识
DOI:10.1021/acs.nanolett.2c03051
摘要
DNA has received increasing attention in nanotechnology due to its ability to fold into prescribed structures. Different from the commonly adopted base-pairing strategy, an emerging class of amorphous DNA materials are formed by DNA’s abiological interactions. Despite the great successes, a lack of nanoscale nucleation/growth control disables more advanced considerations. This work aims at harnessing the heterogeneous nucleation of metal-ion-glued DNA condensates on nanointerfaces. Upon unveiling key orthogonal factors including solution pH, ionic cross-linkers, and surface functionalities, chemically programmable DNA condensation on nanoparticle seeds is achieved, resembling a famous Stöber process for silica coating. The nucleation rules discovered on individual nanoseeds can be passed on to their dimeric assemblies, where broken spherical symmetry and the existence of interparticle gaps help a regiospecific DNA gelation. The steerable DNA condensation, and the multifunctions from DNA, metal ions, and nanocores, hold a great promise in noncanonical DNA nanotechnology toward novel applications.
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