艾普沃思嗜睡量表
安慰剂
阻塞性睡眠呼吸暂停
随机对照试验
医学
荟萃分析
精神运动警觉任务
多次睡眠潜伏期试验
莫达非尼
物理疗法
多导睡眠图
睡眠障碍
呼吸暂停
麻醉
内科学
失眠症
白天过度嗜睡
睡眠剥夺
精神科
昼夜节律
替代医学
病理
作者
Gonzalo Labarca,Rodrigo Montenegro,Grace Oscullo,Mario Henríquez‐Beltrán,Juan Pablo Uribe,José Daniel Gómez-Olivas,Alberto García‐Ortega,Miguel Ángel Martínez‐García
标识
DOI:10.1016/j.smrv.2022.101720
摘要
Sleepiness is one of the outcomes most used in randomized clinical trials (RCT) on the effect of treatments for obstructive sleep apnea (OSA). Furthermore, it is known that there is a placebo effect, especially in subjective measures. Therefore, given that sleepiness is a subjective measure, the objective of this systematic review with meta-analysis and three-level meta-regression was to assess the response to different placebos (pills and sham-CPAP) used in RCTs in OSA, both on subjective (Epworth Sleepiness Scale [ESS]) and objective (Multiple Sleep Latency Test [MSLT], Maintenance Wake Test [MWT], the Osler test and the Psychomotor Vigilance Task [PVT]). We observed a statistically significant placebo effect in both subjective and objective measures of hypersomnia, and in both sham-CPAP and pills. This placebo effect was greater, even clinically significant, in subjective measures (ESS: -2.84 points) and in those RCTs that used pills as a placebo. In the meta-regression, only a higher baseline value of the ESS and Osler test was related to the placebo effect.
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