药物基因组学
精神科
精神分裂症(面向对象编程)
精神病
萧条(经济学)
生物精神病学
基因分型
医学
药物遗传学
心理学
心理治疗师
临床心理学
药理学
生物
遗传学
基因型
基因
宏观经济学
经济
作者
M. Jukić,F. Milosavljević,Espen Molden,Magnus Ingelman‐Sundberg
标识
DOI:10.1016/j.tips.2022.09.011
摘要
Genetic factors can, to a certain extent, successfully predict the therapeutic effects, metabolism, and adverse reactions of drugs. This research field, pharmacogenomics, is well developed in oncology and is currently expanding in psychiatry. Here, we summarize the latest development in pharmacogenomic psychiatry, where results of several recent large studies indicate a true benefit and cost-effectiveness of pre-emptive genotyping for more successful psychotherapy. However, it is apparent that we still lack knowledge of many additional heritable genetic factors of importance for explanation of the interindividual differences in response to psychiatric drugs. Thus, more effort to further develop pharmacogenomic psychiatry should be invested to achieve a broader clinical implementation.
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