夹持器
执行机构
计算机科学
自动化
电阻式触摸屏
千分尺
纳米技术
生物医学工程
材料科学
人工智能
工程类
机械工程
计算机视觉
作者
Richard D. Smith,Ilya Kolb,Shinsuke Tanaka,Albert K. Lee,T.D. Harris,Mladen Barbic
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2022-11-10
卷期号:11
被引量:3
摘要
A wide range of techniques in neuroscience involve placing individual probes at precise locations in the brain. However, large-scale measurement and manipulation of the brain using such methods have been severely limited by the inability to miniaturize systems for probe positioning. Here, we present a fundamentally new, remote-controlled micropositioning approach composed of novel phase-change material-filled resistive heater micro-grippers arranged in an inchworm motor configuration. The microscopic dimensions, stability, gentle gripping action, individual electronic control, and high packing density of the grippers allow micrometer-precision independent positioning of many arbitrarily shaped probes using a single piezo actuator. This multi-probe single-actuator design significantly reduces the size and weight and allows for potential automation of microdrives. We demonstrate accurate placement of multiple electrodes into the rat hippocampus in vivo in acute and chronic preparations. Our robotic microdrive technology should therefore enable the scaling up of many types of multi-probe applications in neuroscience and other fields.
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