Bioinspired Total Syntheses of Gymnothelignans

Abstract Since 2012, Xu and Zhou have reported the isolation of a series of gymnotheligans, a large group of novel tetrahydrofuran-containing lignan natural products. In the past decade, considerable achievements in the total syntheses of these lignans have been achieved based on a plausible biogenetic pathway proposed by our group in 2014. In this account, we summarize these remarkable synthetic works of the past ten years. 1 Introduction 2 Biogenetic Pathways to Gymnothelignans 3 Total Syntheses of Eupodienones 4 Total Syntheses of Eupomatilones 5 Total Synthesis of Dibenzocyclooctenes 6 Conclusions