蜂胶
抗菌剂
化学
食品科学
作文(语言)
肺炎克雷伯菌
微生物学
大肠杆菌
传统医学
生物
生物化学
医学
语言学
哲学
基因
作者
Sual Tatlısulu,Erkay Özgör
标识
DOI:10.1016/j.fbio.2022.102273
摘要
Propolis is a raw natural product produced by Apis mellifera for hive defence. Scientists have also investigated propolis in terms of different biological activities such as antimicrobial and anticancer effects for many years. Its activities depend on the chemical composition of propolis and the composition is changed according to the botanical origin and sampling site. In this study, 13 propolis samples were collected from different locations in Cyprus and ethanolic extraction of Cyprus Propolis (EECP) composition was analysed by GC-MS analysis. In total, there are 78 compounds were found in EECP. Three concentrations (200, 100 and 50 μg/ml) of EECP treated with breast cancer cell lines (MCF-7 and MDA-MB-231) at 24 h and 48 h for determined antiproliferation activity. All EECP, except EECP5 and EECP6, inhibit proliferation activity at all concentrations. Difference between exception samples and all others is the deficiency of 8-βH-cedran-8-ol. Three concentrations of EECP also treated with nosocomial bacteria and results showed EECPs prevented proliferation on Escherichia coli and Pseudomonas aeruginosa while no effect observed on Klebsiella pneumoniae. This situation might be due to the fact that K. pneumoniae is encapsulated. In conclusion, it has been determined that Cyprus propolis, which contains different active compounds, especially 8-βH-cedran-8-ol, is a potential product against infectious diseases and breast cancer proliferation.
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