Natural Brominated Fatty Acid‐Containing Flavonoids Bromaliphflas A–B from Marine‐Derived Streptomyces qinglanensis 1678

Two new brominated fatty acid‐containing flavonoids (1−2), together with the known compound 5‐hydroxy‐3′,4′,7‐trimethoxyflavone (HTMF) (3), were obtained from marine‐derived Streptomyces qinglanensis 1678. The structures of the new isolates were established on the basis of their ESI‐HRMS, 1D and 2D NMR datasets. Bioactivity results show that compounds 2−3 exhibited moderate anti‐inflammatory bioactivities. It seems that HTMF substitution could enhance the bioactivities of the anti‐inflammatory bioactivities of 8‐bromohexanoic acid, however the influence of 6/8‐bromohexanoic acid on the anti‐inflammatory bioactivities of HTMF may depend on the length of the fatty chain.