亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis

微塑料 氧化应激 谷胱甘肽 超氧化物歧化酶 活性氧 碱性磷酸酶 生物 乳酸脱氢酶 肝功能 化学 内科学 生物化学 医学 生态学
作者
Yu Sun,Qingfang Deng,Qiurong Zhang,Xin Zhou,Ruhai Chen,Siyu Li,Qing Wu,Huaguo Chen
出处
期刊:Marine Environmental Research [Elsevier BV]
卷期号:196: 106423-106423 被引量:19
标识
DOI:10.1016/j.marenvres.2024.106423
摘要

Microplastics (5 mm - 1 μm) have become one of the major pollutants in the environment. Numerous studies have shown that microplastics can have negative impacts on aquatic organisms, affecting their liver function levels. However, the extent of these effects and their potential toxicological mechanisms are largely unknown. In this study, a meta-analysis and systematic review were conducted to assess the effects of microplastics on fish liver function and summarize the potential toxicological mechanisms of microplastic-induced liver toxicity. The meta-analysis results indicate that compared to the control group, exposure to microplastics significantly affects fish liver indicators: aspartate aminotransferase (AST) (p < 0.001), alanine aminotransferase (ALT) (p < 0.001), alkaline phosphatase (ALP) (p < 0.001), total protein (TP) (p < 0.001), and lactate dehydrogenase (LDH) (p < 0.001), including oxidative stress indicators: superoxide dismutase (SOD) (p < 0.001), glutathione S-transferase (GST) (p < 0.001), glutathione (GSH) (p < 0.001), and malondialdehyde (MDA) (p < 0.001) in fish liver. For fish living in different environments, the potential toxicological mechanisms of microplastics exposure on fish liver may exhibit some differences. For freshwater fish, the mechanism may be that microplastics exposure causes overproduction of reactive oxygen species (ROS) in fish hepatocyte mitochondria. ROS promotes the expression of toll-like receptor 2 (TLR2) and activates downstream molecules myeloid differentiation factor 88 (MyD88) and tumor necrosis factor receptor-associated factor 6 (TRAF6) of the TLR2 signaling pathway, leading to phosphorylation of NF-κB p65. This leads to the release of inflammatory factors and oxidative stress and inflammation in fish liver. In addition, for seawater fish, the mechanism may be that microplastics exposure can cause damage or death of fish hepatocytes, leading to continuous pathological changes, inflammation, lipid and energy metabolism disorders, thereby causing significant changes in liver function indexes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wdxx发布了新的文献求助30
2秒前
liufan完成签到 ,获得积分10
27秒前
lmplzzp完成签到,获得积分10
30秒前
橙子味的邱憨憨完成签到 ,获得积分10
34秒前
杪夏二八完成签到 ,获得积分10
50秒前
wdxx完成签到,获得积分10
56秒前
649981108发布了新的文献求助10
1分钟前
1分钟前
649981108完成签到,获得积分10
1分钟前
1分钟前
研友_892kOL完成签到,获得积分10
2分钟前
脑洞疼应助李小猫采纳,获得10
2分钟前
2分钟前
李小猫完成签到,获得积分10
2分钟前
2分钟前
李小猫发布了新的文献求助10
2分钟前
3分钟前
3分钟前
3分钟前
5分钟前
5分钟前
Tiger完成签到,获得积分10
5分钟前
5分钟前
6分钟前
Ma发布了新的文献求助10
6分钟前
6分钟前
6分钟前
科研通AI5应助Ma采纳,获得10
6分钟前
彼岸花开发布了新的文献求助10
6分钟前
7分钟前
易四夕发布了新的文献求助10
7分钟前
7分钟前
科研通AI2S应助科研通管家采纳,获得10
7分钟前
Ma发布了新的文献求助10
7分钟前
1234完成签到,获得积分10
7分钟前
岁和景明完成签到 ,获得积分10
7分钟前
科研通AI5应助Ma采纳,获得10
7分钟前
西蓝花香菜完成签到 ,获得积分10
8分钟前
8分钟前
8分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167214
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638