生物
失调
病毒学
肠道菌群
病毒
微生物学
免疫系统
免疫学
作者
Zecai Zhang,Jiang Huang,Chuang Li,Zhicheng Zhao,Yueqi Cui,Xueying Yuan,Xue Wang,Haibo Liu,Yulong Zhou,Zhanbo Zhu
摘要
Whether the high infection rate of BVDV is related to gut microbiota has not been reported. In addition, most studies on BVDV focus on in vitro experiments, which limits the study of its prevention and control strategy and its pathogenic mechanism. In this study, we successfully confirmed the causal relationship between gut microbiota and BVDV infection as well as the potential molecular mechanism based on a mouse model of BVDV infection and a mouse model of gut microbiota dysbiosis. Meanwhile, a mouse model which is more susceptible to BVDV provided in this study lays an important foundation for further research on prevention and control strategy of BVDV and its pathogenesis. In addition, the antiviral effect of butyrate, the metabolites of butyrate-producing bacteria, has been further revealed. Overall, our findings provide a promising prevention and control strategy to treat this infectious disease which is distributed worldwide.
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