胚乳
拟南芥
人类受精
信号(编程语言)
生物
细胞生物学
植物
遗传学
计算机科学
基因
突变体
程序设计语言
作者
Sara Simonini,Stefano Bencivenga,Ueli Grossniklaus
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-02-09
卷期号:383 (6683): 646-653
标识
DOI:10.1126/science.adj4996
摘要
In multicellular organisms, sexual reproduction relies on the formation of highly differentiated cells, the gametes, which await fertilization in a quiescent state. Upon fertilization, the cell cycle resumes. Successful development requires that male and female gametes are in the same phase of the cell cycle. The molecular mechanisms that reinstate cell division in a fertilization-dependent manner are poorly understood in both animals and plants. Using Arabidopsis , we show that a sperm-derived signal induces the proliferation of a female gamete, the central cell, precisely upon fertilization. The central cell is arrested in S phase by the activity of the RETINOBLASTOMA RELATED1 (RBR1) protein. Upon fertilization, delivery of the core cell cycle component CYCD7;1 causes RBR1 degradation and thus S phase progression, ensuring the formation of functional endosperm and, consequently, viable seeds.
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