Cu‐catalyzed dehydrogenative CO arylation for the synthesis of 6‐methyl benzofuro[3,2‐c] quinoline derivatives

Abstract A novel strategy for the synthesis of 6‐methyl benzofuro[3,2‐ c ] quinoline derivatives via copper‐catalyzed dehydrogenative CO arylation has been presented. Optimization studies have been carried out by varying various catalysts, bases, solvents, and other physical parameters. Keeping use of this dehydrogenative cross‐coupling CO arylation reaction, a variety of bioactive building blocks like fused benzofuro quinoline heterocycles were smoothly assembled in moderate to higher yields.