氮氧化物4
缺氧(环境)
肺动脉高压
间歇性缺氧
NADPH氧化酶
医学
阿普辛尼
高海拔对人类的影响
内科学
心脏病学
肺动脉
药理学
内分泌学
化学
氧化应激
氧气
阻塞性睡眠呼吸暂停
有机化学
解剖
作者
Shaohua Li,Qiang Liu,Qingqing Shi,Yuxiang Bai,Xue Ren,Jing Ma
出处
期刊:Clinical Science
[Portland Press]
日期:2024-01-18
摘要
High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease that can lead to right heart failure. Intermittent short-duration reoxygenation at high altitude is effective in alleviating HAPH; however, the underlying mechanisms are unclear. In this study, a simulated 5,000-m hypoxia rat model and hypoxic cultured pulmonary artery smooth muscle cells (PASMCs) were used to evaluate the effect and mechanisms of intermittent short-duration reoxygenation. The results showed that intermittent 3-hour/per day reoxygenation (I3) effectively attenuated chronic hypoxia-induced pulmonary hypertension and reduced the content of H2O2 and the expression of NADPH oxidase 4 (NOX4) in lung tissues. In combination with I3, while the NOX inhibitor apocynin did not further alleviate HAPH, the mitochondrial antioxidant MitoQ did. Furthermore, in PASMCs, I3 attenuated hypoxia-induced PASMCs proliferation and reversed the activated HIF-1α/NOX4/PPAR-γ axis under hypoxia. Targeting this axis offset the protective effect of I3 on hypoxia-induced PASMCs proliferation. This study is novel in revealing a new mechanism for preventing HAPH and provides insights into the optimization of intermittent short-duration reoxygenation.
科研通智能强力驱动
Strongly Powered by AbleSci AI