原肌球蛋白受体激酶B
变构调节
神经科学
trk受体
跨膜结构域
原肌球蛋白受体激酶A
神经营养因子
脑源性神经营养因子
神经营养素
化学
细胞生物学
生物
药理学
受体
生物化学
作者
Giray Enkavi,Mykhailo Girych,Rafael Moliner,Ilpo Vattulainen,Eero Ċastrén
标识
DOI:10.1016/j.tibs.2024.02.001
摘要
TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane cholesterol, which bidirectionally regulates TrkB signaling. Additionally, TrkB has recently been recognized as a binding target of antidepressant drugs. A variety of different antidepressants, including typical and rapid-acting antidepressants, as well as psychedelic compounds, act as allosteric potentiators of BDNF signaling through TrkB. This suggests that TrkB is the common target of different antidepressant compounds. Although more research is needed, current knowledge suggests that TrkB is a promising target for further drug development.
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