毒素
赤眼蜂
戒毒(替代医学)
生物
真菌毒素
镰刀菌
黄曲霉毒素
体内
二乙酰氧基癸酚
肝损伤
药理学
微生物学
医学
生物技术
遗传学
替代医学
病理
作者
Wenxi Song,Youshuang Wang,Tingyu Huang,Yu Liu,Fengjuan Chen,Chen Yun-he,Yibao Jiang,Cong Zhang,Xu Yang
标识
DOI:10.1016/j.envpol.2023.121784
摘要
T-2 toxin, a type A trichothecene, is a secondary metabolite produced by Fusarium poae, Fusarium sporotrichioides, and Fusarium tricinctum. As the most toxic trichothecenes, T-2 toxin causes severe damage to multiple organs, especially to liver. However, the contamination of T-2 toxin covers a wide range of plants, including nuts, grains, fruits and herbs globally. And due to chemical stability of T-2 toxin, it is difficult to be completely removed from the food and feeds, which poses a great threat to human and animal health. Liver is the major detoxifying organ which also makes it the main target of T-2 toxin. After being absorbed by intestine, the first pass effect will reduce the level of T-2 toxin in blood indicating that liver is the main metabolic site of T-2 toxin in vivo. In this review, updated researches on the hepatotoxicity of T-2 toxin were summarized. The metabolic characteristic of T-2 toxin in vivo was introduced. The main hepatotoxic mechanisms of T-2 toxin are oxidative stress, mitochondrial damage, deoxyribonucleic acid (DNA) methylation, autophagy and apoptosis. The remission of the hepatotoxicity induced by T-2 toxin was also studied in this review followed by new findings on the detoxification of hepatotoxicity induced by T-2 toxin. The review aimed to offer a comprehensive view and proposes new perspectives in the field of hepatotoxicity induced by T-2 toxin.
科研通智能强力驱动
Strongly Powered by AbleSci AI