化学
离子迁移光谱法
门控
离子
还原(数学)
过程(计算)
压缩(物理)
分析化学(期刊)
质谱法
色谱法
生物物理学
材料科学
几何学
数学
有机化学
计算机科学
复合材料
生物
操作系统
作者
Qimu Yang,Yiqian Xu,Manman Pan,Dandan Jiang,Zhenxin Wang,Weiguo Wang,Xianzhe Shi,Chuang Chen,Haiyang Li
标识
DOI:10.1021/acs.analchem.4c00582
摘要
The broad applications of ion mobility spectrometry (IMS) demand good sensitivity and resolving power for ion species with different reduced mobilities (K0). In this work, a new Tyndall–Powell gate (TPG) gating method for combining ion enrichment, mobility discrimination reduction, and temporal compression into a single gating process is proposed to improve IMS analysis performance. The two-parallel-grid structure and well-confined gate region of the TPG make it convenient to spatiotemporally vary the electric fields within and around the gate region. Under the new gating method, a potential wave is applied on TPG grid 1 to enrich ions within the ionization region adjacent to the TPG during the gate-closed state; meanwhile, a potential wave is applied on TPG grid 2 to enhance mobility discrimination reduction and temporal compression simultaneously during the gate-open state. For triethyl phosphate (TEP) and dimethyl methylphosphonate mixtures, product ion peaks within K0 of 1.9 to 1.1 cm2/V·s exhibit a 19-fold increase in ion current compared to the traditional TPG gating method, while maintaining a resolving power of 85. The estimated limit of detection for the TEP dimer is lowered from 8 ppb to 135 ppt. The new gating method can be applied to other TPG-based IMS systems to enhance their performance in analyzing complex samples.
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