对映选择合成
分子内力
催化作用
金属羰基
化学
选择性
羰基
有机化学
组合化学
金属
立体化学
作者
Linjun Qi,Bo Zhou,Long‐Wu Ye
标识
DOI:10.1002/chem.202401389
摘要
Transition‐metal‐catalyzed epoxidation of carbonyl compounds through carbonyl ylides represents a highly effective method for synthesizing a diverse range of valuable epoxides. This review offers an in‐depth overview of the latest developments in inter‐ and intramolecular epoxidation reactions involving metal carbenes and carbonyl compounds, encompassing both racemic to enantioselective transformations. These catalytic epoxidations are reviewed by highlighting their product selectivity, diversity and applicability, and the related mechanistic rationale is showcased where possible.
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