Treatment of central centrifugal cicatricial alopecia with topical metformin 10% cream: case report and literature review

International Journal of DermatologyEarly View Letter to the Editor Treatment of central centrifugal cicatricial alopecia with topical metformin 10% cream: case report and literature review Bárbara Vieira Granja, Corresponding Author Bárbara Vieira Granja [email protected] orcid.org/0000-0002-9032-787X Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this authorPedro Rolo De Matos, Pedro Rolo De Matos orcid.org/0000-0002-4208-7939 Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorGilberto Pires Rosa, Gilberto Pires Rosa Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal RISE@CINTESIS, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this authorJorge Pinheiro, Jorge Pinheiro Department of Pathology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorFilomena Azevedo, Filomena Azevedo Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorAna Filipa Pedrosa, Ana Filipa Pedrosa Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal RISE@CINTESIS, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this author Bárbara Vieira Granja, Corresponding Author Bárbara Vieira Granja [email protected] orcid.org/0000-0002-9032-787X Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this authorPedro Rolo De Matos, Pedro Rolo De Matos orcid.org/0000-0002-4208-7939 Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorGilberto Pires Rosa, Gilberto Pires Rosa Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal RISE@CINTESIS, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this authorJorge Pinheiro, Jorge Pinheiro Department of Pathology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorFilomena Azevedo, Filomena Azevedo Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, PortugalSearch for more papers by this authorAna Filipa Pedrosa, Ana Filipa Pedrosa Department of Dermatology and Venereology, Unidade Local de Saúde São João, Porto, Portugal RISE@CINTESIS, Faculty of Medicine, University of Porto, Porto, PortugalSearch for more papers by this author First published: 23 June 2024 https://doi.org/10.1111/ijd.17345 Conflict of interest: None. Funding source: None. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Lawson CN, Bakayoko A, Callender VD. Central centrifugal cicatricial alopecia: challenges and treatments. Dermatol Clin. 2021; 39: 389–405. 10.1016/j.det.2021.03.004 CASPubMedWeb of Science®Google Scholar 2Aguh C, Dina Y, Talbot CC Jr, Garza L. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia. J Am Acad Dermatol. 2018; 79: 904–912.e1. 10.1016/j.jaad.2018.05.1257 CASPubMedWeb of Science®Google Scholar 3Wu M, Xu H, Liu J, Tan X, Wan S, Guo M, et al. Metformin and fibrosis: a review of existing evidence and mechanisms. J Diabetes Res. 2021; 2021:6673525. 10.1155/2021/6673525 PubMedWeb of Science®Google Scholar 4Markowicz-Piasecka M, Huttunen KM, Mateusiak L, Mikiciuk-Olasik E, Sikora J. Is metformin a perfect drug? Updates in pharmacokinetics and pharmacodynamics. Curr Pharm Des. 2017; 23: 2532–2550. 10.2174/1381612822666161201152941 CASPubMedWeb of Science®Google Scholar 5Araoye EF, Thomas JAL, Aguh CU. Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. JAAD Case Rep. 2020; 6: 106–108. 10.1016/j.jdcr.2019.12.008 PubMedGoogle Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation