病毒学
接种疫苗
血凝素(流感)
免疫学
医学
疾病
生物
病毒
病理
作者
Zhaochen Luo,Hector A. Miranda,Kaitlyn N. Burke,M. Ariel Spurrier,Michael Berry,Erica Stover,Rachel L. Spreng,Greg Waitt,Erik J. Soderblom,Andrew N. Macintyre,Kevin Wiehe,Nicholas S. Heaton
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2024-05-01
卷期号:16 (745)
标识
DOI:10.1126/scitranslmed.adj4685
摘要
Current seasonal influenza virus vaccines induce responses primarily against immunodominant but highly plastic epitopes in the globular head of the hemagglutinin (HA) glycoprotein. Because of viral antigenic drift at these sites, vaccines need to be updated and readministered annually. To increase the breadth of influenza vaccine-mediated protection, we developed an antigenically complex mixture of recombinant HAs designed to redirect immune responses to more conserved domains of the protein. Vaccine-induced antibodies were disproportionally redistributed to the more conserved stalk of the HA without hindering, and in some cases improving, antibody responses against the head domain. These improved responses led to increased protection against homologous and heterologous viral challenges in both mice and ferrets compared with conventional vaccine approaches. Thus, antigenically complex protein mixtures can at least partially overcome HA head domain antigenic immunodominance and may represent a step toward a more universal influenza vaccine.
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