Cadmium Therapeutic Agents

螯合疗法 乙二胺四乙酸 螯合作用 镉中毒 毒性 毒物动力学 医学 药理学 毒理 化学 生理学 生物 内科学 有机化学
作者
Colleen Kelley,David E. Sargent,Jennifer K. Uno
出处
期刊:Current Pharmaceutical Design [Bentham Science Publishers]
卷期号:5 (4): 229-240 被引量:60
标识
DOI:10.2174/1381612805666230109212741
摘要

Pollution of the environment with toxic metals has increased dramatically since the beginning of the industrial revolution. Cadmium is of particular concern because it accumulates in the human body with a half-life exceeding IO years and has been Jinked with a number of health problems including renal tubular dysfunction, pulmonary emphysema, significant kidney damage, and possibly osteoporosis. Moreover, in 1993 the International Agency for Research on Cancer (IARC) classified cadmium and compounds containing cadmium as human carcinogens. The field of cadmium intoxication therapy has seen increases in interest due to its poignant toxicity in both humans and animals. Preliminary attempts to combat acute cadmium poisoning included the use of the chelating agents ethylenediaminetetraacetic acid (EDTA) and British anti-Lewisite (BAL). This review will focus on the chemistry, biology, and effectiveness of cadmium intoxication therapy to date. The toxicokinetics of cadmium mammals will be discussed briefly to understand the extent and severity of overexposure. An overview of cadmium chelation therapy will be given with an e_mphasis on the measurable effectiveness of each and significant structure activity relationships. Cadmium intoxication therapy will be reviewed by their indicated routes of action: direct (chelation and antagonism), indirect (induction), and symptom alleviation. The methods by which cadmium therapeutics are evaluated (in vivo, in vitro) are to be discussed. An evaluation of the clinical potential for promising therapeutics will be given.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
铅笔刀发布了新的文献求助10
刚刚
潘尼发布了新的文献求助10
刚刚
金刚大王完成签到,获得积分10
刚刚
1秒前
天天喝咖啡完成签到,获得积分10
1秒前
雪白的威完成签到,获得积分10
1秒前
Wv完成签到,获得积分10
1秒前
顺利半梦完成签到,获得积分10
2秒前
2秒前
2秒前
2秒前
还单身的寒云完成签到,获得积分10
2秒前
nothing完成签到,获得积分10
3秒前
溪夕er完成签到,获得积分10
3秒前
mogu完成签到,获得积分10
3秒前
sh33完成签到,获得积分10
3秒前
13发布了新的文献求助10
3秒前
3秒前
3秒前
黄耀完成签到,获得积分10
3秒前
戚雅柔完成签到 ,获得积分10
4秒前
善学以致用应助Yoo.采纳,获得10
4秒前
由由完成签到 ,获得积分10
4秒前
刘晓丹完成签到,获得积分10
4秒前
Derek0203完成签到,获得积分10
5秒前
刘运丽完成签到,获得积分10
5秒前
羊羊完成签到,获得积分10
5秒前
某某完成签到,获得积分10
5秒前
陈思完成签到,获得积分10
5秒前
ikun完成签到,获得积分10
5秒前
Queen完成签到,获得积分10
5秒前
6秒前
菲菲高完成签到 ,获得积分10
6秒前
cff完成签到 ,获得积分10
6秒前
6秒前
yubaibai完成签到,获得积分10
7秒前
小许会更好完成签到,获得积分10
7秒前
7秒前
ooa4321发布了新的文献求助10
7秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968771
求助须知:如何正确求助?哪些是违规求助? 3513646
关于积分的说明 11169065
捐赠科研通 3249011
什么是DOI,文献DOI怎么找? 1794589
邀请新用户注册赠送积分活动 875236
科研通“疑难数据库(出版商)”最低求助积分说明 804740