🔥 科研通第二届『应助活动周』重磅启航,3月24-30日求助秒级响应🚀,千元现金等你拿。详情 📚 中科院2025期刊分区📊 已更新

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

多药耐受 癌细胞 生物 癌症 遗传学 细菌 生物膜
作者
François M. Vallette,Olivier D. Christophe,Frédéric Lézot,Lisa Oliver,Denis Cochonneau,Lisenn Lalier,Pierre‐François Cartron,Dominique Heymann
出处
期刊:Biochemical Pharmacology [Elsevier]
卷期号:162: 169-176 被引量:160
标识
DOI:10.1016/j.bcp.2018.11.004
摘要

Although many drugs/treatments are now available for most diseases, too often, resistance to these treatments impedes complete therapeutic success. Acquired resistance is a major problem in many pathologies but it is an acute one in cancers and infections. This is probably because these diseases often require long durations of treatment, which ascribe to the selection of resistant cells. However, the actual mechanisms implicated in the selection process are still under debate. It is becoming increasingly clear that resistance is associated with the heterogeneity of cancer cells or micro-organisms and that multiple mechanisms underlie the emergence of drug-resistant subpopulations. Recently, it has been suggested that a subpopulation of drug tolerant cells present in cancer populations and called play a major role in this resistance. Recent studies have shown that microorganisms share similar properties. Still, how persister/tolerant cells intervene in the development of resistance is not completely elucidated but seems to be related to epigenetic changes in treated cells and the capacity of persisters to modulate and/or highjack their microenvironment. Due to the complexity of this process, the input from mathematicians, as well as new methods of bioinformatics and statistics, is necessary to fully comprehend the acquisition of resistance/tolerance deriving from and leading to the heterogeneous cell populations. The present review will give a brief overview of the most recent data available on drug tolerant cells in cancers and their similarities with microorganisms.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
清爽的乐曲完成签到,获得积分10
刚刚
巧克力完成签到 ,获得积分10
刚刚
Eloise完成签到,获得积分10
2秒前
Yunlong完成签到,获得积分10
3秒前
3秒前
薄荷小新完成签到 ,获得积分10
3秒前
在阳光下完成签到 ,获得积分10
4秒前
永不言弃完成签到 ,获得积分10
5秒前
7秒前
7秒前
英姑应助不信慕斯采纳,获得10
8秒前
轻松的鑫完成签到 ,获得积分10
10秒前
冻手手的南瓜粥完成签到,获得积分10
11秒前
李小飞Li完成签到,获得积分10
12秒前
满意外套完成签到,获得积分10
13秒前
ll完成签到 ,获得积分10
13秒前
牛马要毕业完成签到,获得积分10
13秒前
jbear完成签到 ,获得积分10
16秒前
16秒前
long完成签到 ,获得积分10
17秒前
ding应助Steven采纳,获得10
19秒前
20秒前
22秒前
科研通AI2S应助激动的猫咪采纳,获得10
22秒前
23秒前
23秒前
24秒前
大古熬汤变成光完成签到,获得积分10
25秒前
zhangruiii完成签到,获得积分10
25秒前
25秒前
25秒前
今夕何夕发布了新的文献求助10
26秒前
田様应助乌梅橘子茶采纳,获得10
26秒前
27秒前
27秒前
闪闪的妙竹完成签到 ,获得积分10
28秒前
29秒前
wcy完成签到 ,获得积分10
30秒前
不信慕斯发布了新的文献求助10
30秒前
30秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Conference Record, IAS Annual Meeting 1977 1150
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Neuromuscular and Electrodiagnostic Medicine Board Review 800
Teaching language in context (3rd edition) by Derewianka, Beverly; Jones, Pauline 610
EEG in clinical practice 2nd edition 1994 600
Barth, Derrida and the Language of Theology 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 计算机科学 纳米技术 化学工程 复合材料 基因 遗传学 催化作用 物理化学 细胞生物学 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 3604549
求助须知:如何正确求助?哪些是违规求助? 3172658
关于积分的说明 9575495
捐赠科研通 2878770
什么是DOI,文献DOI怎么找? 1581178
邀请新用户注册赠送积分活动 743447
科研通“疑难数据库(出版商)”最低求助积分说明 725935