银屑病
表皮生长因子受体
癌症研究
信号转导
酪氨酸激酶
表皮生长因子受体抑制剂
表皮(动物学)
受体酪氨酸激酶
医学
受体
生物
细胞生物学
免疫学
内科学
解剖
作者
Sijia Wang,Zhuoli Zhang,Han Peng,Kang Zeng
出处
期刊:PubMed
日期:2019-01-01
卷期号:11 (2): 520-528
被引量:39
摘要
Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses. Several dermatologic diseases including psoriasis are related to the anomalous activation of EGFR signaling. It has been proved that the expression and activity of EGFR and its endogenous ligands are overexpressed in the active epidermis lesions of psoriasis. Moreover, the remarkable therapeutic improvement of chronic psoriasis in cancer patients during the treatment of EGFR inhibitors or anti-EGFR monoclonal antibodies are also recorded, suggesting that the EGFR-mediated signaling may conduct a crucial role in the pathophysiology of psoriasis.
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