A prospective cohort study on the effect of epidural labor analgesia on syndecan-1 in patients with preeclampsia

ObjectiveTo evaluate the treatment effects of epidural labor analgesia on syndecan-1 in patients with preeclampsia. MethodsDuring Jan., 2016 and Dec., 2017, 150 unipara females with preeclampsia and gestational age>37 weeks were enrolled in the prospective cohort study.They were devided into intervention and control group (n=75 in each group) with and without epidural labor analgesia, based on whether epidural labor analgesia applications were made by the patients at the first examination of cervical dilation of 2 cm.The primary outcomes were mean change and change rate of syndecan-1 from baseline to 2 h post-treatment, and the secondary outcomes were visual analogue scale (VAS), IL-6 level and mean arterial pressure (MAP). ResultsAbsolute change of syndecan-1 from baseline to 2 h post-baseline was (-11.49±82.80) ng/mL in the intervention group and (45.09±55.14) ng/mL in the control group, respectively.There was a significant difference in mean change of syndecan-1 between the two groups (P < 0.001).Similarly, the intervention group exhibited a greater reduction in change rate of syndecan-1 compared with the control group (P < 0.001).Moreover, the intervention group had greater reduction in VAS and MAP compared with the control group (P < 0.001 for both).There was no significant difference in IL-6 level between the two groups. ConclusionsEpidural labor analgesia was associated with greater reduction in syndecan-1, VAS and MAP compared with the control condition.In contrast, administration of epidural analgesia did not significantly change IL-6 level.