Targeted Therapy Recommendations for Therapy Refractory Solid Tumors—Data from the Real-World Precision Medicine Platform MONDTI

医学 靶向治疗 耐火材料(行星科学) 内科学 肿瘤科 精密医学 间皮瘤 联合疗法 癌症治疗 癌症 病理 天体生物学 物理
作者
Hossein Taghizadeh,Matthias Unseld,Martina Spalt,Robert M. Mader,Leonhard Müllauer,Thorsten Fuereder,Markus Raderer,Maria Sibilia,Mir Alireza Hoda,Stefanie Aust,Stephan Polterauer,Wolfgang Lamm,Rupert Bartsch,Matthias Preusser,Alexandra Kautzky‐Willer,Gerald W. Prager
出处
期刊:Journal of Personalized Medicine [Multidisciplinary Digital Publishing Institute]
卷期号:10 (4): 188-188 被引量:7
标识
DOI:10.3390/jpm10040188
摘要

Advanced therapy-refractory solid tumors bear a dismal prognosis and constitute a major challenge in offering effective treatment strategies. In this real-world retrospective analysis of our precision medicine platform MONDTI, we describe the molecular profile of 554 patients diagnosed with 17 different types of advanced solid tumors after failure of all standard treatment options. In 304 cases (54.9% of all patients), a molecular-driven targeted therapy approach could be recommended, with a recommendation rate above 50% in 12 tumor entities. The three highest rates for therapy recommendation per tumor classification were observed in urologic malignancies (90.0%), mesothelioma (78.6%), and male reproductive cancers (71.4%). Tumor type (p = 0.46), expression of p-mTOR (p = 0.011), expression of EGFR (p = 0.046), and expression of PD-L1 (p = 0.023) had a significant impact on the targeted therapy recommendation rate. Therapy recommendations were significantly more often issued for men (p = 0.015) due to gender-specific differences in the molecular profiles of patients with head and neck cancer and malignant mesothelioma. This analysis demonstrates that precision medicine was feasible and provided the basis for molecular-driven therapy recommendations in patients with advanced therapy refractory solid tumors.
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