乳腺癌
三阴性乳腺癌
试剂
化学
癌症研究
纳米棒
细胞内
生物物理学
材料科学
纳米技术
癌症
生物化学
医学
生物
内科学
物理化学
作者
Yang Du,Chuang Yang,Fangyuan Li,Hongwei Liao,Zheng Chen,Peihua Lin,Nan Wang,Yan Zhou,Ji Young Lee,Qiang Ding,Daishun Ling
出处
期刊:Small
[Wiley]
日期:2020-06-09
卷期号:16 (31)
被引量:31
标识
DOI:10.1002/smll.202002537
摘要
Abstract Triple‐negative breast cancer (TNBC) is highly aggressive and insensitive to conventional targeted therapies, resulting in poor therapeutic outcomes. Recent studies have shown that abnormal iron metabolism is observed in TNBC, suggesting an opportunity for TNBC treatment via the iron‐dependent Fenton reaction. Nevertheless, the efficiency of current Fenton reagents is largely restricted by the lack of specificity and low intracellular H 2 O 2 level of cancer cells. Herein, core–shell–satellite nanomaces (Au @ MSN@IONP) are fabricated, as near‐infrared (NIR) light‐triggered self‐fueling Fenton reagents for the amplified Fenton reaction inside TNBC cells. Specifically, the Au nanorod core can convert NIR light energy into heat to induce massive production of intracellular H 2 O 2 , thereby the surface‐decorated iron oxide nanoparticles (IONP) are being fueled for robust Fenton reaction. By exploiting the vulnerability of iron efflux in TNBC cells, such a self‐fueling Fenton reaction leads to highly specific anti‐TNBC efficacy with minimal cytotoxicity to normal cells. The PI3K/Akt/FoxO axis, intimately involved in the redox regulation and survival of TNBC, is demonstrated to be inhibited after the treatment. Consequently, precise in vivo orthotopic TNBC ablation is achieved under the guidance of IONP‐enhanced magnetic resonance imaging. The results demonstrate the proof‐of‐concept of NIR‐light‐triggered self‐fueling Fenton reagents against TNBC with low ferroportin levels.
科研通智能强力驱动
Strongly Powered by AbleSci AI