亚硝胺
化学
亚硝基
制造工艺
审查
有机化学
药物化学
致癌物
材料科学
哲学
神学
复合材料
作者
Rocío López‐Rodríguez,James A. McManus,Natasha S. Murphy,Martin A. Ott,Michael J. Burns
标识
DOI:10.1021/acs.oprd.0c00323
摘要
Recent drug recalls (e.g., valsartan and ranitidine) linked to the discovery of nitrosamine impurities have led to increased regulatory scrutiny in the manufacturing process of marketed medicines, notably for determining any sources of risk for nitrosamine (or related N-nitroso compound) formation within the manufacturing process. This review seeks to aid the risk assessment process through identifying known conditions and reactants through which N-nitroso compounds can be formed.
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