Transcriptional regulation of adaptive and innate lymphoid lineage specification

生物 关贸总协定3 先天性淋巴细胞 转录因子 FOXP3型 细胞分化 细胞生物学 T细胞 免疫学 获得性免疫系统 遗传学 基因 抗原 免疫系统
作者
Camille A. Spinner,Vanja Lazarevic
出处
期刊:Immunological Reviews [Wiley]
卷期号:300 (1): 65-81 被引量:41
标识
DOI:10.1111/imr.12935
摘要

Abstract Once alerted to the presence of a pathogen, activated CD4 + T cells initiate distinct gene expression programs that produce multiple functionally specialized T helper (Th) subsets. The cytokine milieu present at the time of antigen encounter instructs CD4 + T cells to differentiate into interferon‐(IFN)‐γ‐producing Th1 cells, interleukin‐(IL)‐4‐producing Th2 cells, IL‐17‐producing Th17 cells, follicular T helper (Tfh) cells, or regulatory T (Treg) cells. In each of these Th cell subsets, a single transcription factor has been identified as a critical regulator of its specialized differentiation program. In this context, the expression of the “master regulator” is necessary and sufficient to activate lineage‐specific genes while restricting the gene expression program of alternative Th fates. Thus, the transcription factor T‐bet controls Th1 differentiation program, while the development of Th2, Th17, Tfh, and Treg cells is dependent on transcription factors GATA3, RORγt, Bcl6, and Foxp3, respectively. Nevertheless, master regulators or, more precisely, lineage‐defining transcription factors do not function in isolation. In fact, they interact with a complex network of transcription factors, orchestrating cell lineage specification programs. In this review, we discuss the concept of the combinatorial interactions of key transcription factors in determining helper T cell identity. Additionally, lineage‐defining transcription factors have well‐established functions beyond their role in CD4 + Th subsets. They play critically important functions at distinct stages during T cell development in the thymus and they control the development of innate lymphoid cells (ILCs) in the bone marrow. In tracking the journey of T cells traversing from the thymus to the periphery and during the immune response, we discuss in broad terms developmental stage and context‐dependent functions of lineage‐defining transcription factors in regulating specification programs of innate and adaptive lymphocytes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
4秒前
充电宝应助NVLEKU采纳,获得10
4秒前
5秒前
5秒前
天天快乐应助zhu采纳,获得10
6秒前
IRer79发布了新的文献求助10
6秒前
量子星尘发布了新的文献求助10
6秒前
麦丰完成签到,获得积分10
6秒前
6秒前
likke完成签到,获得积分20
7秒前
7秒前
FashionBoy应助li采纳,获得10
8秒前
8秒前
SciGPT应助薛定谔的猫采纳,获得10
8秒前
9秒前
9秒前
muming完成签到,获得积分20
10秒前
sanlunainiu发布了新的文献求助10
10秒前
林博研完成签到,获得积分20
10秒前
FashionBoy应助风趣的灵枫采纳,获得10
11秒前
12秒前
yihuiqing发布了新的文献求助10
13秒前
likke发布了新的文献求助10
13秒前
嗝嗝发布了新的文献求助10
13秒前
小兔狸花昕完成签到,获得积分20
14秒前
IRer79完成签到,获得积分10
16秒前
彭于晏应助noah采纳,获得10
16秒前
青年才俊发布了新的文献求助10
16秒前
zhu发布了新的文献求助10
17秒前
波波蛋完成签到,获得积分10
17秒前
18秒前
19秒前
20秒前
maguodrgon发布了新的文献求助10
23秒前
科研通AI5应助shell采纳,获得80
23秒前
波波蛋发布了新的文献求助10
23秒前
24秒前
九鹤完成签到,获得积分10
24秒前
jsy完成签到,获得积分10
24秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387