Pro‐Healing Zwitterionic Skin Sensor Enables Multi‐Indicator Distinction and Continuous Real‐Time Monitoring

Abstract In both artificial electronic and ionic skins, the distinction of multi‐stimuli response in a single sensing unit is challenging, due to unavoidable mutual signal interference. Here, a zwitterionic skin sensor system that can continuously monitor and differentiate three‐stimuli‐responsive information in real‐time is designed. This sandwich‐structured sensor system is based on a zwitterionic thermo–glucose‐sensitive skin‐like hydrogel at its upper and lower layers with a middle isolation elastomer layer, enabling monitoring and distinction of temperature, mechanical and glucose information without signal interference: 1) the capacitance of the upper/lower layers as glucose–temperature‐insensitive is variable to measure strain; 2) the resistance of the upper hydrogel as glucose‐insensitive is variable to measure strain and temperature; and 3) the resistance of the lower hydrogel can detect three indicators. Based on the skin sensor system, a smart wound dressing is developed to pro‐heal chronic diabetic wounds and enable continuous real‐time monitoring of three indicators—infection, swelling, and blood glucose. This work provides a new method of real‐time monitoring and the distinction of multi‐stimuli response in a wearable device.