脚手架
软骨发生
生物医学工程
间充质干细胞
组织工程
细胞外基质
骨关节炎
材料科学
关节软骨修复
软骨
再生(生物学)
3D生物打印
基质(化学分析)
细胞生物学
解剖
医学
关节软骨
病理
生物
复合材料
替代医学
作者
Yanzhi Liu,Liuqi Peng,Lingli Li,Cuishan Huang,Keda Shi,Xiangbo Meng,Pinpin Wang,Mingming Wu,Ling Li,Huijuan Cao,Kefeng Wu,Qingqiang Zeng,Haobo Pan,William W. Lu,Ling Qin,Changshun Ruan,Xinluan Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2021-12-01
卷期号:279: 121216-121216
被引量:100
标识
DOI:10.1016/j.biomaterials.2021.121216
摘要
Osteochondral defect repair in osteoarthritis (OA) remains an unsolved clinical problem due to the lack of enough seed cells in the defect and chronic inflammation in the joint. To address this clinical need, we designed a bone marrow-derived mesenchymal stem cell (BMSC)-laden 3D-bioprinted multilayer scaffold with methacrylated hyaluronic acid (MeHA)/polycaprolactone incorporating kartogenin and β-TCP for osteochondral defect repair within each region. BMSC-laden MeHA was designed to actively introduce BMSCs in situ, and diclofenac sodium (DC)-incorporated matrix metalloproteinase-sensitive peptide-modified MeHA was induced on the BMSC-laden scaffold as an anti-inflammatory strategy. BMSCs in the scaffolds survived, proliferated, and produced large amounts of cartilage-specific extracellular matrix in vitro. The effect of BMSC-laden scaffolds on osteochondral defect repair was investigated in an animal model of medial meniscectomy-induced OA. BMSC-laden scaffolds facilitated chondrogenesis by promoting collagen II and suppressed interleukin 1β in osteochondral defects of the femoral trochlea. Congruently, BMSC-laden scaffolds significantly improved joint function of the injured leg with respect to the ground support force, paw grip force, and walk gait parameters. Therefore, this research demonstrates the potential of 3D-bioprinted BMSC-laden scaffolds to simultaneously inhibit joint inflammation and promote cartilage defect repair in OA joints.
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