结直肠癌
微生物群
基因组
肠道微生物群
表观遗传学
肠道菌群
癌症
生物
肿瘤转化
大肠癌小鼠模型的建立
恶性转化
癌症研究
医学
免疫学
癌变
生物信息学
遗传学
基因
作者
Ann Zeuner,Maria Laura De Angelis,Federica Francescangeli
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2022-01-01
卷期号:: 357-369
标识
DOI:10.1016/b978-0-12-819265-8.00029-2
摘要
Colorectal cancer is sharply increasing in young adults, likely due to a progressive accumulation of epigenetic alterations linked to environmental and nutritional factors. Intestinal cancer is highly related to lifestyle and dietary habits, which play a crucial role in shaping the intestinal microbiome. While metagenomic studies are expanding the number of pro-carcinogenic bacterial strains, an increased understanding of the mechanisms linking gut microbiota to neoplastic transformation will likely lead to new strategies for promoting intestinal health and preventing the onset of colorectal cancer.
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