Fabrication and application of a rutin electrochemical sensor based on rose-like AuNPs-MoS2-GN composite and molecularly imprinted chitosan

A molecularly imprinted polymer/ Au nanoparticles-MoS2-graphene/GCE sensor was fabricated and used for the electrochemical detection of rutin. The rose-like Au nanoparticles-MoS2 -graphene composite (AuNPs-MoS2-GN) was fabricated by using a one-pot hydrothermal method. Graphene acted as an efficient matrix for the growth of MoS2 nanoflower (NF), and the edges of the MoS2 NF subsequently loaded AuNPs. The AuNPs-MoS2-GN composite had large specific surface area, good conductivity and high catalysis, and showed excellent electrochemical response to rutin. To improve the selectivity, rutin imprinted chitosan film was electrodeposited on the AuNPs-MoS2-GN/GCE. The obtained molecularly imprinted sensor had strong adsorption capacity for rutin. Under the optimized conditions, the sensor showed a low detection limit (i.e. 4 nmol L−1) and a wide detection range (i.e. 0.01–45.0 μmol L−1). It also displayed high stability and selectivity. When the sensor was applied to the determination of rutin in real samples satisfactory results were achieved.