生物
病毒学
病毒
干扰素
细胞病变效应
鼠疫病毒
Ⅰ型干扰素
怀孕
胎儿
免疫学
微生物学
病毒性疾病
黄病毒科
遗传学
作者
Bryan Charleston,Martin Fray,Susan J. Baigent,B. Veronica Carr,W. Ivan Morrison
标识
DOI:10.1099/0022-1317-82-8-1893
摘要
The establishment of persistent infections with non-cytopathic bovine virus diarrhoea virus (ncpBVDV) is crucial for the maintenance of BVDV in cattle populations. Also, super-infection of persistently infected individuals with antigenically homologous cytopathic BVDV (cpBVDV) results in fatal mucosal disease. Persistent infection with ncpBVDV is established by infection of the foetus during the first trimester of pregnancy. It has been shown previously that foetal infection with cpBVDV does not result in persistent infection. Infection of cells in vitro has demonstrated that cpBVDV induces type I interferon (IFN), whereas ncpBVDV fails to induce IFN. In this study we demonstrate that foetal challenge with cpBVDV results in IFN production, whereas ncpBVDV does not. These findings strongly suggest that the ability of ncpBVDV to inhibit the induction of type I IFN has evolved to enable the virus to establish persistent infection in the early foetus.
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