医学
宫颈上皮内瘤变
宫颈锥切术
子宫切除术
宫颈癌
相对风险
妇科
置信区间
单变量分析
上皮内瘤变
子宫颈
泌尿科
内科学
癌症
多元分析
外科
前列腺
作者
Jeong-Yeol Park,Seung Mi Lee,Chong Woo Yoo,Sokbom Kang,Sang-Yoon Park,Seung‐Woo Seo
标识
DOI:10.1016/j.ygyno.2007.05.014
摘要
Objective. To determine factors predicting post-cone residual disease in cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Methods. Of 337 patients who underwent conization due to CIN III and microinvasive cervical cancer between November 2001 and March 2006, 77 underwent hysterectomy within 6 months of conization. We analyzed their demographic features, pathologic parameters and pre-cone high-risk human papilloma virus (HR-HPV) load measured by Digene Hybrid Capture II. Results. In univariate analysis, age ≥50 years (P=0.048, relative risk [RR]=2.74, 95% confidence interval [CI]=1.0–7.4), positive resection margin (P=0.004, RR=4.35, 95% CI=1.5–12.3), and pre-cone HR-HPV load ≥300 relative light units (RLU)/positive control (PC) (P=0.009, RR=3.41, 95% CI=1.3–8.7) were significant factors associated with residual disease. While postmenopausal status showed borderline significance (P=0.065, RR=2.65, 95% CI=0.9–7.5), parity ≥3, severity of disease (CIN III vs. microinvasive cancer), conization method (large loop excision of transformation zone vs. cold knife conization), and glandular extension were not significant. In multivariate analysis only positive margin (P=0.023, RR=3.56, 95% CI=1.2–10.7) and pre-cone HR-HPV load ≥300 RLU/PC (P=0.034, RR=2.96, 95% CI=1.1–8.1) were significant factors associated with residual disease. Conclusion. Positive margin and pre-cone HR-HPV load ≥300 RLU/PC were the only significant factors predicting post-cone residual disease in multivariate analysis. Appropriate application of these predictive factors may avoid post-cone hysterectomy.
科研通智能强力驱动
Strongly Powered by AbleSci AI