生物物理学
膜
刚度(电磁)
化学物理
生物分子
分子间力
位阻效应
生物
表面粗糙度
离解(化学)
纳米技术
材料科学
分子
物理
化学
立体化学
生物化学
物理化学
复合材料
量子力学
作者
Anne Pierrès,Virginie Monnet‐Corti,Anne‐Marie Benoliel,Pierre Bongrand
标识
DOI:10.1016/j.tcb.2009.05.009
摘要
Cells sense physical properties of their environment including substratum rigidity, roughness, and topography of recognition sites. The cell surface displays continuous deformations of nanometer-scale amplitude and Hz frequency. Recent results support the hypothesis that these surface undulations constitute a powerful strategy for the rapid acquisition of environmental cues: transient contact with surroundings generates forces of piconewton intensity as a result of rapid formation and dissociation of intermolecular bonds. The combination of binding and steric forces is expected to drive conformational changes and lateral reorganization of membrane biomolecules, thus generating signaling cascades. We propose that spontaneous membrane mobility shapes the initial information generated by cell-to-surface contacts, and thereby biases later consequences of these interactions.
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