阿霉素
心脏毒性
蒽环类
肌酸激酶
医学
内质网
内科学
白细胞减少症
药理学
毒性
内分泌学
化学
化疗
生物化学
癌症
乳腺癌
作者
G. Zbinden,A.K. Beilstein
标识
DOI:10.1016/0378-4274(82)90163-1
摘要
Two new anthracenediones with antineoplastic activities resembling those of the anthracycline antibiotics were studied in a rat cardiotoxicity model system. NSC-196473 was approx. 10-fold less toxic than doxorubicin and caused only minor electrocardiogram (ECG) changes. Its dihydroxyanalog NSC-279836 was somewhat more toxic than doxorubicin, caused marked leukopenia and induced ECG changes and moderate elevation of serum GOT, LDH and creatine phosphokinase (CK). Both anthracenediones induced marked alterations of mitochondrial structure in the heart but no dilatation of the sarcoplasmic reticulum and distortion of the contractile elements. It is concluded that the cardiotoxic effects of the anthracenediones are of a less specific nature than those caused by doxorubicin.
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