Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity

再现性 激光多普勒测速 斑点图案 医学 生物医学工程 血流 心脏病学 材料科学 核医学 光学 数学 物理 统计
作者
Matthieu Roustit,C. Millet,S. Blaise,Boris Dufournet,Jean‐Luc Cracowski
出处
期刊:Microvascular Research [Elsevier BV]
卷期号:80 (3): 505-511 被引量:269
标识
DOI:10.1016/j.mvr.2010.05.012
摘要

We compared the inter-day reproducibility of post-occlusive reactive hyperemia (PORH) assessed by single-point laser Doppler flowmetry (LDF) and laser speckle contrast analysis (LSCI), and the reproducibility of local thermal hyperemia (LTH) assessed by LDF, laser Doppler imaging (LDI) and LSCI. We also tested whether skin blood flow assessment by LDF and by LSCI are correlated. Skin blood flow was evaluated during PORH and LTH using LDF, LDI (for LTH only) and LSCI on the forearms of healthy volunteers, at a 7 day interval. Data are expressed as cutaneous vascular conductance (CVC), as a function of baseline and scaled to the thermal plateau. Reproducibility is expressed as within subject coefficients of variation (CV, in %) and intra-class correlation coefficients (ICC). Twenty-eight healthy participants were enrolled in this study. The reproducibility of the PORH peak CVC was better when assessed with LSCI compared to LDF (CV = 8%; ICC = 0.76 and CV = 30%; ICC = 0.54, respectively). Inter-day reproducibility of the LTH plateau was better when assessed with LSCI or LDI than LDF (CV = 15%, ICC = 0.66; CV = 17%, ICC = 0.51 and CV = 42%, ICC = 0.28 respectively). Finally, we observed significant correlation between simultaneous LDF and LSCI measurements of the PORH peak CVC (R = 0.54; p = 0.001). The recently developed LSCI technique showed very good inter-day reproducibility for assessing PORH and LTH. Moreover, we showed significant correlation between LSCI and single-point LDF for PORH. However, more data are needed to evaluate the linearity between the LSCI signal and skin blood flow.
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