神经发生
脑出血
神经干细胞
人脑
神经科学
病理
祖细胞
生物
干细胞
医学
细胞生物学
内科学
蛛网膜下腔出血
作者
Jianfeng Shen,Lin Xie,Xiao‐Ming Mao,Yong-Qing Zhou,Renya Zhan,David A. Greenberg,Kunlin Jin
标识
DOI:10.1038/jcbfm.2008.37
摘要
Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and is induced in response to brain injury and neurodegenerative disease. Whether intracerebral hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary intracerebral hemorrhage (n=5). Cells in this region also expressed cell proliferation markers, which colocalized to the same cells that expressed neural stem/progenitor cell-specific proteins. Our data suggest that intracerebral hemorrhage induces neurogenesis in the adult human brain.
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