清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

医学 哮喘 嗜酸性粒细胞 内科学 恶化 队列 比率 体质指数 前瞻性队列研究 队列研究 置信区间 优势比 肺结核 病理
作者
David Price,Anna Rigazio,Jonathan D. Campbell,Eugene R. Bleecker,Christopher J. Corrigan,Mike Thomas,Sally E. Wenzel,A WILSON,Mary Buatti Small,Gokul Gopalan,Valerie L. Ashton,Anne Burden,Elizabeth V. Hillyer,Marjan Kerkhof,Ian Pavord
出处
期刊:The Lancet Respiratory Medicine [Elsevier BV]
卷期号:3 (11): 849-858 被引量:522
标识
DOI:10.1016/s2213-2600(15)00367-7
摘要

Elevated sputum eosinophil counts predict asthma exacerbations and responsiveness to inhaled corticosteroids but are impractical to measure in primary care. We investigated the relation between blood eosinophil count and prospective annual asthma outcomes for a large UK cohort.This historical cohort study used anonymised medical record data to identify primary care patients with asthma aged 12-80 years with 2 years of continuous records, including 1 year before (baseline) and 1 year after (outcome) their most recent eosinophil count. Negative binomial regression was used to compare outcome exacerbation rates and logistic regression to compare odds of asthma control for patients with blood eosinophil counts of 400 cells per μL or less versus greater than 400 cells per μL, adjusting for age, sex, body-mass index, smoking status, and Charlson comorbidity index. The study is registered at ClinicalTrials.gov, number NCT02140541.Overall, 20 929 (16%) of 130 248 patients had blood eosinophil counts greater than 400 cells per μL. During the outcome year, these patients experienced significantly more severe exacerbations (adjusted rate ratio [RR] 1·42, 95% CI 1·36-1·47) and acute respiratory events (RR 1·28, 1·24-1·33) than those with counts of 400 cells per μL or less. They also had significantly lower odds of achieving overall asthma control (OR 0·74, 95% CI 0·72-0·77), defined as limited reliever use and no asthma-related hospital attendance or admission, acute course of oral corticosteroids, or prescription for antibiotics. Exacerbation rates increased progressively with nine ascending categories of blood eosinophil count as compared with a reference category of 200 cells per μL or less.Patients with asthma and blood eosinophil counts greater than 400 cells per μL experience more severe exacerbations and have poorer asthma control. Furthermore, a count-response relation exists between blood eosinophil counts and asthma-related outcomes. Blood eosinophil counts could add predictive value to Global Initiative for Asthma control-based risk assessment.Teva Pharmaceuticals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
刚刚
FashionBoy应助无辜的发卡采纳,获得10
2秒前
量子星尘发布了新的文献求助30
12秒前
12秒前
17秒前
23秒前
量子星尘发布了新的文献求助10
24秒前
25秒前
啊呀麦克发布了新的文献求助10
30秒前
35秒前
无辜的发卡完成签到,获得积分10
38秒前
澜生完成签到 ,获得积分10
41秒前
wujiwuhui完成签到 ,获得积分10
42秒前
量子星尘发布了新的文献求助10
42秒前
啊呀麦克发布了新的文献求助10
42秒前
45秒前
量子星尘发布了新的文献求助10
49秒前
量子星尘发布了新的文献求助10
57秒前
啊呀麦克发布了新的文献求助10
59秒前
四叶草完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
笨笨完成签到 ,获得积分10
1分钟前
啊呀麦克发布了新的文献求助10
1分钟前
碗碗豆喵完成签到 ,获得积分10
1分钟前
1分钟前
坚强白凝发布了新的文献求助10
1分钟前
creep2020完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
FashionBoy应助科研通管家采纳,获得10
1分钟前
1分钟前
Jasper应助坚强白凝采纳,获得10
1分钟前
颜陌完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
科研通AI2S应助jlwang采纳,获得10
1分钟前
2分钟前
西山菩提完成签到,获得积分10
2分钟前
斯文的傲珊完成签到,获得积分10
2分钟前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
Statistical Methods for the Social Sciences, Global Edition, 6th edition 600
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
ALUMINUM STANDARDS AND DATA 500
Walter Gilbert: Selected Works 500
岡本唐貴自伝的回想画集 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3666414
求助须知:如何正确求助?哪些是违规求助? 3225448
关于积分的说明 9763022
捐赠科研通 2935282
什么是DOI,文献DOI怎么找? 1607589
邀请新用户注册赠送积分活动 759266
科研通“疑难数据库(出版商)”最低求助积分说明 735188