Additive effect of the metabolic syndrome score to the conventional CHADS2 score for the thromboembolic risk stratification of patients with atrial fibrillation

医学 心房颤动 内科学 CHA2DS2–血管评分 代谢综合征 接收机工作特性 血栓栓塞性中风 心脏病学 血栓形成 人口 冲程(发动机) 危险分层 缺血性中风 缺血 环境卫生 工程类 肥胖 机械工程
作者
Chia‐Ti Tsai,Shui‐Feng Chang,Sheng‐Nan Chang,Juey‐Jen Hwang,Cho‐Kai Wu,Yi‐Chih Wang,Chuen-Den Tseng,Huei‐Ming Yeh,Ling‐Ping Lai,Fu‐Tien Chiang,Jiunn-Lee Lin
出处
期刊:Heart Rhythm [Elsevier BV]
卷期号:11 (3): 352-357 被引量:15
标识
DOI:10.1016/j.hrthm.2013.11.014
摘要

Background The CHA2DS2-VASC scoring scheme may not be better than the CHADS2 scoring scheme in predicting thromboembolic risk for patients with atrial fibrillation (AF) in Asians. Metabolic syndrome is associated with an increased risk of thrombosis. Objective To evaluate whether metabolic syndrome offers incremental information over the CHADS2 scheme in predicting thromboembolic risk for patients with AF in the Taiwanese population. Methods The study population consisted of 721 consecutive patients with AF who had been followed up for a median of 10.8 years. Thromboembolic end points were defined as ischemic stroke/transient ischemic accident and peripheral embolisms. Clinical factors associated with thromboembolic end points were identified by Cox regression analysis. Different scoring systems were compared by receiver operating characteristic (ROC) analysis. Results We found that components in the CHADS2 scheme were associated with an increased risk of thromboembolism. The CHA2DS2-VASC scheme did not provide information additional to that provided by the CHADS2 scheme on thromboembolism risk (ROC area: 0.670 vs 0.665; P > .05). Metabolic syndrome components were also associated with increased risk of thromboembolism. The incident thromboembolic rate increased incrementally when metabolic syndrome score increased. Additional metabolic syndrome components provide additional information to the CHADS2 scheme on thromboembolism risk (ROC area: 0.670 vs 0.729; P = .034). We therefore proposed a new scoring scheme called CHADS2-MS scoring scheme. In patients with low to intermediate CHADS2 scores (0–1), the use of the CHADS2-MS score may additionally identify patients with high-risk AF for future thromboembolism. Conclusions We, for the first time, demonstrated that metabolic syndrome components were associated with thromboembolic risk in Taiwanese patients with AF. In addition to the conventional CHADS2 scheme, the calculation of the CHADS2-MS score provides additional information on stroke risk assessment. The CHA2DS2-VASC scoring scheme may not be better than the CHADS2 scoring scheme in predicting thromboembolic risk for patients with atrial fibrillation (AF) in Asians. Metabolic syndrome is associated with an increased risk of thrombosis. To evaluate whether metabolic syndrome offers incremental information over the CHADS2 scheme in predicting thromboembolic risk for patients with AF in the Taiwanese population. The study population consisted of 721 consecutive patients with AF who had been followed up for a median of 10.8 years. Thromboembolic end points were defined as ischemic stroke/transient ischemic accident and peripheral embolisms. Clinical factors associated with thromboembolic end points were identified by Cox regression analysis. Different scoring systems were compared by receiver operating characteristic (ROC) analysis. We found that components in the CHADS2 scheme were associated with an increased risk of thromboembolism. The CHA2DS2-VASC scheme did not provide information additional to that provided by the CHADS2 scheme on thromboembolism risk (ROC area: 0.670 vs 0.665; P > .05). Metabolic syndrome components were also associated with increased risk of thromboembolism. The incident thromboembolic rate increased incrementally when metabolic syndrome score increased. Additional metabolic syndrome components provide additional information to the CHADS2 scheme on thromboembolism risk (ROC area: 0.670 vs 0.729; P = .034). We therefore proposed a new scoring scheme called CHADS2-MS scoring scheme. In patients with low to intermediate CHADS2 scores (0–1), the use of the CHADS2-MS score may additionally identify patients with high-risk AF for future thromboembolism. We, for the first time, demonstrated that metabolic syndrome components were associated with thromboembolic risk in Taiwanese patients with AF. In addition to the conventional CHADS2 scheme, the calculation of the CHADS2-MS score provides additional information on stroke risk assessment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
如梦发布了新的文献求助10
刚刚
iwww发布了新的文献求助10
1秒前
从容灵松发布了新的文献求助10
1秒前
夏天呀完成签到,获得积分10
2秒前
乖猫要努力应助浅浅采纳,获得10
2秒前
zzzzzzz发布了新的文献求助10
2秒前
生动的翠容完成签到,获得积分10
3秒前
yy关闭了yy文献求助
3秒前
musejie发布了新的文献求助10
4秒前
坚果发布了新的文献求助10
4秒前
5秒前
Andy1201应助Hatexist采纳,获得50
5秒前
Jasmine发布了新的文献求助10
5秒前
6秒前
彳亍发布了新的文献求助10
6秒前
彭于晏应助gwff采纳,获得10
6秒前
6秒前
曼凡发布了新的文献求助10
7秒前
8秒前
8秒前
zzzzzzz完成签到,获得积分10
8秒前
大模型应助wangchaofk采纳,获得10
9秒前
禾风发布了新的文献求助10
9秒前
wang123发布了新的文献求助20
9秒前
好奇宝宝发布了新的文献求助10
10秒前
10秒前
元谷雪发布了新的文献求助10
10秒前
陌疑应助白鸽鸽采纳,获得10
11秒前
陶醉元冬完成签到,获得积分10
12秒前
12秒前
NJP发布了新的文献求助10
12秒前
111发布了新的文献求助10
13秒前
淡淡雨琴发布了新的文献求助10
13秒前
13秒前
史彦钊完成签到,获得积分10
14秒前
吴大打发布了新的文献求助10
14秒前
美梦成真完成签到,获得积分10
14秒前
欢喜芒果完成签到,获得积分10
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971277
求助须知:如何正确求助?哪些是违规求助? 3515939
关于积分的说明 11180280
捐赠科研通 3251061
什么是DOI,文献DOI怎么找? 1795664
邀请新用户注册赠送积分活动 875937
科研通“疑难数据库(出版商)”最低求助积分说明 805209