脑膜炎奈瑟菌
奈瑟菌科
病毒学
奈瑟菌
医学
微生物学
地理
生物
抗生素
细菌
遗传学
作者
Bianca Stenmark,Sara Thulin Hedberg,Susanne Jacobsson,Hans Fredlund,Per Olcén,Paula Mölling
出处
期刊:Eurosurveillance
[European Centre for Disease Control and Prevention (ECDC)]
日期:2014-10-23
卷期号:19 (42)
被引量:18
标识
DOI:10.2807/1560-7917.es2014.19.42.20940
摘要
An increase of invasive meningococcal disease caused by Neisseria meningitidis serogroup Y has been noted in Sweden since 2005, and to a lower extent throughout Europe. The present study describes the epidemiology of invasive N. meningitidis isolates in Sweden in the period between 2010 and 2012, with a focus on serogroup Y. We also aimed to find an optimal molecular typing scheme for both surveillance and outbreak investigations. All invasive N. meningitidis isolates in Sweden during the study period (n=208) were genetically characterised. Serogroup Y predominated with 22/57, 31/61 and 44/90 of all invasive isolates (incidence 0.23, 0.33 and 0.46 per 100,000 population) in 2010, 2011 and 2012 respectively. In each of these years, 15/22, 22/31 and 19/44 of serogroup Y isolates were genetically clonal (Y: P1.5–2,10–1,36–2: F4–1: ST-23(cc23), ‘porB allele 3–36, fHbp allele 25 and penA allele 22). Our findings further support those of others that currently recommended FetA typing could be replaced by FHbp. Moreover, in line with a previous study that we conducted, the current results indicate that highly variable multilocus variable-number tandem repeat analysis (HV-MLVA) can be used as a first-hand rapid method for small outbreak investigations.
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