Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease

额叶 心理学 临床痴呆评级 痴呆 神经心理学 听力学 口语流利性测试 颞叶 评定量表 疾病 流利 运动功能 内科学 医学 神经科学 认知 物理医学与康复 发展心理学 癫痫 数学教育
作者
Tomoyuki Nagata,Shunichiro Shinagawa,Yusuke Ochiai,Hirohide KADA,Hiroo Kasahara,Kazutaka Nukariya,Kazuhiko Nakayama
出处
期刊:International Psychogeriatrics [Cambridge University Press]
卷期号:22 (3): 463-469 被引量:33
标识
DOI:10.1017/s1041610209991323
摘要

ABSTRACT Background: In order to address the neuropsychological pathogenesis of aberrant motor behaviors in Alzheimer's disease (AD), we used a cross-sectional study design to investigate the association between frontal lobe function, including executive function, and activity disturbances (wandering, purposeless activities and inappropriate activities). Methods: Among 75 consecutive outpatients with AD, 50 subjects with a Clinical Dementia Rating (CDR) score of 1 or 2 were selected and divided into two groups based on data obtained from interviews with their caregivers: an aberrant motor behaviors (AMB) group (n = 22), and a non-aberrant motor behaviors (NAMB) group (n = 28). Aberrant motor behavior was defined according to whether the “activity disturbance” score (ranging from 0 to 9) of the Behavioral Pathology in Alzheimer Disease (Behave-AD) scale was 0 or ≥1. The total and subtest scores of the Frontal Assessment Battery (FAB) were then compared between the two groups. Results: Significant differences were found between the FAB total ( P < 0.05) and the subtest scores (lexical fluency, conflicting instructions; P < 0.05) in the two groups. The FAB score was significantly associated with the activity disturbance score (r = −0.49; P <0.001). A stepwise multiple regression analysis showed that only the FAB score significantly influenced the activity disturbance score ( P < 0.001). Conclusions: This finding suggested that in addition to episodic memory disturbance, frontal lobe dysfunctions might lead patients with AD to develop aberrant motor behavior.
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