补骨脂
去卵巢大鼠
骨质疏松症
雌激素
成骨细胞
Wnt信号通路
内分泌学
内科学
化学
医学
体内
药理学
体外
生物
信号转导
生物化学
生物技术
替代医学
病理
作者
Zebin Weng,Qianqian Gao,Fang Wang,Genhua Zhao,Fangzhou Yin,Baochang Cai,Zhipeng Chen,Weidong Li
标识
DOI:10.1016/j.mce.2015.09.025
摘要
Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, long-term supplement of estrogen may cause uterine hyperplasia and hypertension leading to a high risk of endometrial cancer and breast cancer. Psoralea corylifolia L. has long been used as tonic and food additives in many countries. Previous studies had found two ingredients in P. corylifolia L.: bavachin and bakuchiol exhibited osteoblastic activity. The present study was designed to investigate the protective effect of bakuchiol and bavachin on ovariectomy-induced bone loss and explore the possible mechanism. In vivo, bakuchiol and bavachin could prevented estrogen deficiency-induced bone loss in ovariectomized rats without uterotrophic activity. In vitro studies suggested that bakuchiol and bavachin induced primary human osteoblast differentiation by up-regulating the Wnt signalling pathway. This study suggests that such a bone-protective role makes them a promising and safe estrogen supplement for the ERT.
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