Structure-activity Relationship of Sintenin and its Analogues on Six Human Tumor Cell Lines

The synthesis of a cytotoxic natural ester sintenin 1 and thirty-three of its analogues 2-34 were carried out. The cytotoxicities of the synthetic compounds have been screened for human tumor cell lines such as PC-3, Hela, A549, BEL7404, CNE, and KB. The results showed that phenolic derivatives exhibited strongest cytoxicity, and the unsaturated esters were more cytotoxic than their saturated analogues.