Transcriptional regulation of lipid biosynthesis, related target validation and drug discovery

Disorders in lipid biosynthesis is a key aspect of metabolic disorders, and is associated with many disease, including hyperlipidemia, insulin resistance, atherosclerosis, osteoporosis, and tumors. In transcriptional level, sterol regulating element binding protein (SREBP) and liver X receptor (LXR) are respectively responsible for regulation of lipid biosynthesis and transports, and thus play key roles in lipid metabolism. Both SREBP and LXR control signalling networks and are interconnected with each other, leading to the balance of lipid metabolism. PGC-1β is the key co-activator for SREBP, LXR and ERRa, and is of great importance in regulating lipid biosynthesis and transports.