Enantioselective indium(i)-catalyzed [4 + 2] annulation of alkoxyallenes and β,γ-unsaturated α-keto esters

An indium(i)–chiral phosphoric acid complex was found to catalyze the enantioselective [4 + 2] annulation reaction of β,γ-unsaturated α-keto esters with alkoxyallenes, affording cyclic O,O-acetals in good yields and with high regio- and stereo-selectivities.