Mouse and human share conserved transcriptional programs for interneuron development

Surveying brain interneuron development As transient structures in early brain development, the ganglionic eminences generate dozens of different types of interneurons that go on to migrate throughout and weave together the developing brain. Shi et al . analyzed human fetal ganglionic eminences. Single-cell transcriptomics revealed unexpected diversity in the types of progenitor cells involved. The human ganglionic eminence depends more heavily on intermediate progenitor cells as workhorses than does the developing neocortex, with its greater reliance on radial glial cells. —PJH