红树林
一氧化氮
立体化学
聚酮
真菌
圆二色性
曲霉
二维核磁共振波谱
绝对构型
化学
内生真菌在植物防御中的应用
立体中心
生物
生物化学
微生物学
生物合成
植物
酶
有机化学
对映选择合成
催化作用
生态学
作者
Xiaoya Qin,Jianbin Huang,Dexiong Zhou,Wenxiu Zhang,Yanjun Zhang,Jun Li,Rui‐Yun Yang,Xishan Huang
出处
期刊:Marine Drugs
[MDPI AG]
日期:2021-12-21
卷期号:20 (1): 5-5
被引量:12
摘要
Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1-4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1-3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1-11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.
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