Episodic future thinking: A behavioral intervention to promote weight loss in breast cancer survivors.

医学 减肥 超重 随机对照试验 乳腺癌 心理干预 癌症 生活质量(医疗保健) 肥胖 干预(咨询) 老年学 内科学 精神科 护理部
作者
Jasmine Sukumar,Jennifer Vaughn,Jeffrey S. Stein,Patrick Schnell,Preeti Sudheendra,Ashley Pariser,Margaret E. Gatti‐Mays,Nicole Williams,Mathew Cherian,Daniel G. Stover,Robert Wesolowski,Bhuvaneswari Ramaswamy,Maryam B. Lustberg,Sagar Sardesai
出处
期刊:Journal of Clinical Oncology [Lippincott Williams & Wilkins]
卷期号:40 (16_suppl): TPS12139-TPS12139 被引量:1
标识
DOI:10.1200/jco.2022.40.16_suppl.tps12139
摘要

TPS12139 Background: Obesity at diagnosis is associated with an increase in breast cancer (BC) specific mortality. Behavioral interventions targeting obesity-related health choices offer a scalable approach to improve patient engagement in the community. Episodic Future Thinking (EFT) is a novel remotely delivered behavioral intervention which engages the science of prospection where participants mentally simulate positive, detailed, and personal events that can occur in the future. EFT targets a key behavioral economic measure – Delay Discounting (DD). As DD rate rises, an individual devalues future outcomes to a greater degree and has a higher bias for immediate gratification. EFT can decrease DD in obese patients, leading to improved diet quality and weight loss. However, valuation of the future may impact cancer survivors differently. Herein, we propose the first randomized Phase II trial evaluating adherence and changes in DD and body weight with 12-week remotely delivered EFT vs control in overweight or obese BC survivors. Methods: Eligible patients have a history of DCIS or stage 1 to 3 BC, BMI > 25 kg/m 2 , have completed surgery, radiation, and chemotherapy, and are motivated to lose weight. They are randomized 1:1 to a 12-week EFT intervention or control (Episodic Recent Thinking; ERT). ERT is a validated control in which patients imagine events in the recent past. Randomization will be stratified by baseline DD rate. There is an optional 12 week follow up period where patients can continue to receive EFT or ERT cues. DD will be measured at baseline and every 4 weeks for 24 weeks. The primary endpoint is adherence, measured by percentage of thrice daily smartphone prompts participants open and attend to during the 12-week trial. Secondary endpoints are changes in body weight and DD rate at 12 and 24 weeks and change in PROs (PROMIS scales), insulin resistance (HOMA-IR), hs-CRP, and diet quality (HEI 2015) at 12 weeks from baseline. With 20 subjects per arm, the study has 80% power to detect deviation of 14 points from a target adherence rate of 80% using a 1 sample t-test. The primary endpoint is evaluable for all subjects, regardless of drop-out. Secondary endpoints will be evaluated using a linear mixed effects model. Hypothesis tests and confidence intervals will be two-sided at 5% significance/95% confidence level. Since trial activation in November 2021, 9 of the planned 46 patients are enrolled. Accrual is closely integrated with the dedicated Ohio State University Comprehensive Cancer Center Survivorship Program. This work is supported by the Alliance Cancer Control Program Pilot Award (5UG1CA189823-08). Clinical trial information: NCT05012176.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
曹博发布了新的文献求助10
刚刚
哈哈哈哈发布了新的文献求助10
刚刚
1秒前
郝煜祺完成签到,获得积分10
1秒前
2秒前
范范发布了新的文献求助20
3秒前
Ava应助明亮囧采纳,获得10
4秒前
4秒前
小柚子发布了新的文献求助10
4秒前
orixero应助sln采纳,获得10
5秒前
zumri发布了新的文献求助10
6秒前
马儿饿了要吃草完成签到,获得积分10
6秒前
orixero应助遐蝶采纳,获得10
6秒前
6秒前
万能图书馆应助奇奇采纳,获得10
7秒前
niupotr完成签到,获得积分10
7秒前
8秒前
8秒前
化学y发布了新的文献求助10
8秒前
9秒前
9秒前
打打应助jin晨采纳,获得10
9秒前
星辰大海应助陆仓颉采纳,获得10
10秒前
10秒前
吾问无为谓完成签到,获得积分10
10秒前
方圆学术完成签到,获得积分10
11秒前
华仔应助如愿如慕采纳,获得10
11秒前
ehsl完成签到,获得积分10
12秒前
852应助动听的母鸡采纳,获得10
12秒前
Grim完成签到,获得积分10
12秒前
13秒前
灿灿发布了新的文献求助10
13秒前
13秒前
Forestzoo应助yao chen采纳,获得10
14秒前
Ccc发布了新的文献求助10
14秒前
哈哈哈哈哈完成签到,获得积分10
14秒前
zumri完成签到,获得积分20
15秒前
小琰砸完成签到,获得积分10
15秒前
15秒前
ShaodongLIU发布了新的文献求助10
15秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974856
求助须知:如何正确求助?哪些是违规求助? 3519400
关于积分的说明 11198085
捐赠科研通 3255563
什么是DOI,文献DOI怎么找? 1797860
邀请新用户注册赠送积分活动 877208
科研通“疑难数据库(出版商)”最低求助积分说明 806219