Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry

医学 倾向得分匹配 改良兰金量表 相对风险 内科学 绝对风险降低 置信区间 外科 心脏病学 缺血性中风 缺血
作者
Chunrong Tao,Adnan I. Qureshi,Yamei Yin,Jie Li,Rui Li,Pengfei Xu,Jun Sun,Geng Liao,Xincan Yue,Hongchao Shi,Yongchang Liu,Zhengfei Ma,Jinhua Zhang,Guodong Xiao,Bo Xu,Chenghua Xu,Junfeng Su,Wensheng Zhou,Shuchun Huang,Weimin Yang,Hongbing Chen,Wei Li,Yongkun Li,Dezhi Liu,Chuanqing Yu,Guangxiong Yuan,Chaobin Wang,Wenbao Liang,Chun Chen,Xueying Shi,Junjun Wang,Yingchun Wu,Xueli Cai,Chunyun Shen,Kai Li,Fang Pu,Ming Wang,Zhongjun Chen,Tong Li,Guangsen Cheng,Yaxuan Sun,Yan Wang,Hui Zhang,Jie Chen,Xiaohui Xu,Youmeng Wang,Wanjie Geng,Chuyuan Ni,Changchun Chen,Liu Yan,Jie Min,Yongcheng Zhang,Yong Liang,Chao Wen,Blaise Baxter,Raul G Nogueira,Wei Hu
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
卷期号:146 (1): 6-17 被引量:64
标识
DOI:10.1161/circulationaha.121.058544
摘要

Background: The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO). Methods: The present analysis was based on the ongoing, prospective, multicenter ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) trial registry in China. Our analytic sample comprised 2134 patients recruited at 48 sites between 2017 and 2021 and included 462 patients who received BMM and 1672 patients who received EVT. We performed an inversed probability of treatment weighting analysis. Qualifying patients had to present within 24 hours of estimated BAO. The primary clinical outcome was favorable functional outcome (modified Rankin Scale score, 0–3) at 90 days. We also performed a sensitivity analysis with the propensity score matching–based and the instrumental variable–based analysis. Results: In our primary analysis using the inversed probability of treatment weighting–based analysis, there was a significantly higher rate of favorable outcome at 90 days among EVT patients compared with BMM-treated patients (adjusted relative risk, 1.42 [95% CI, 1.19–1.65]; absolute risk difference, 11.8% [95% CI, 6.9–16.7]). The mortality was significantly lower (adjusted relative risk, 0.78 [95% CI, 0.69–0.88]; absolute risk difference, −10.3% [95% CI, −15.8 to −4.9]) in patients undergoing EVT. Results were generally consistent across the secondary end points. Similar associations were seen in the propensity score matching–based and instrumental variable–based analysis. Conclusions: In this real-world study, EVT was associated with significantly better functional outcomes and survival at 90 days. Well-designed randomized studies comparing EVT with BMM in the acute BAO are needed. Registration: URL: www.chictr.org.cn ; Unique identifier: ChiCTR2000041117.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小丸子发布了新的文献求助10
刚刚
1秒前
1秒前
2秒前
monocle发布了新的文献求助10
6秒前
可爱的函函应助星辰采纳,获得10
6秒前
霸气的代云完成签到 ,获得积分10
7秒前
7秒前
8秒前
8秒前
光芒万丈发布了新的文献求助10
11秒前
12秒前
12秒前
Owen应助踏实语蓉采纳,获得10
12秒前
专注大门发布了新的文献求助10
13秒前
cc发布了新的文献求助10
14秒前
a1459196273完成签到,获得积分10
16秒前
王小嘻发布了新的文献求助30
16秒前
Aaernan发布了新的文献求助10
17秒前
草玉梅皂苷完成签到,获得积分10
18秒前
小二郎发布了新的文献求助10
19秒前
19秒前
bkagyin应助樊书南采纳,获得10
19秒前
沉淀中的黄绿医生完成签到,获得积分10
20秒前
20秒前
武俊怡完成签到,获得积分10
20秒前
充电宝应助Becky采纳,获得10
21秒前
今后应助FUNG采纳,获得10
22秒前
我是老大应助研0被骂儿采纳,获得10
22秒前
飞飞发布了新的文献求助10
25秒前
可靠的大美完成签到,获得积分10
25秒前
我是老大应助月牙超级甜采纳,获得10
29秒前
29秒前
淡定的翠霜关注了科研通微信公众号
29秒前
舒心的青槐完成签到 ,获得积分10
30秒前
火星上以亦完成签到,获得积分10
31秒前
32秒前
背后的问寒完成签到,获得积分10
33秒前
Soul完成签到 ,获得积分20
33秒前
Akim应助小二郎采纳,获得10
36秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3084836
求助须知:如何正确求助?哪些是违规求助? 2737894
关于积分的说明 7547256
捐赠科研通 2387494
什么是DOI,文献DOI怎么找? 1265999
科研通“疑难数据库(出版商)”最低求助积分说明 613212
版权声明 598429