光热治疗
材料科学
纳米复合材料
纳米技术
纳米棒
纳米材料
癌细胞
癌症治疗
光热效应
癌症治疗
癌症
癌症研究
医学
内科学
作者
Meng Wang,Gao-jian Zhou,Nitin Nitin,Yao Xue,Shunhua Zhu,Yuchen Yan,Honghua Yuan,Shibao Li,Qingli Huang
标识
DOI:10.1016/j.matdes.2022.110794
摘要
A graphene quantum dots (GQDs) and manganese dioxide (MnO2) co-decorated, polydopamine (PDA) capped iron oxyhydroxide (FeOOH) nanorod was firstly constructed as a promising platform for magnetic resonance imaging (MRI) guided tumor synergistic therapy. Each component played an irreplaceable role. Tumor microenvironment activated cascade Fenton catalytic activities and MRI capability at different stages were obtained, which can simultaneously realize diagnosis and chemodynamic therapy (CDT) for cancer. In addition, photothermal therapy (PTT) was also achieved owing to the excellent photothermal conversion efficiency of PDA and GQDs, which further improve the Fenton catalytic activities and realized synergistic therapy for cancer. The experimental results showed that only about 30% of cancer cells was killed when CDT or NIR laser alone for cancer inhibition. However, when PTT and CDT were employed simultaneously to treat the cancer cells, the therapeutic efficiency has increased by 300% (90% of cancer cells was killed and about 10% cancer cells survived) due to combinatorial effect of PTT and CDT. Obviously, a more effective treatment of cancer could be realized using MRI guided tumor synergistic therapy with the as-prepared nanocomposites. This study provides a proof of concept of design and construction of complex nanomaterials for cancer diagnosis and treatment.
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